ISSN 1662-4009 (online)

ey0019.8-3 | New Mechanisms | ESPEYB19

8.3. DNA methylation signatures in human neonatal blood following maternal antenatal corticosteroid treatment

B Kim , S Sasaki , K Murphy , SG Matthews

Transl Psychiatry. 2022; 12(1): 132. PMID: 35354798https://pubmed.ncbi.nlm.nih.gov/35354798/Brief Summary: This case control study identified widespread effects of fetal exposure to antenatal maternal glucocorticoid treatment on newborn bloodspot DNA methylation profiles.Antenatal treatment with glucocorticoids (AGC), such as betamethasone or dexamethasone, is widely u...

ey0019.8-1 | Mechanism of the year: neuropeptide substance P regulates aldosterone secretion | ESPEYB19

8.1. The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

K Cheng , Y Seita , T Moriwaki , K Noshiro , Y Sakata , YS Hwang , T Torigoe , M Saitou , H Tsuchiya , C Iwatani , M Hosaka , T Ohkouchi , H Watari , T Umazume , K Sasaki

Sci Adv. 2022; 8(16): eabn8485. PMID: 35442744https://pubmed.ncbi.nlm.nih.gov/35442744/Brief Summary: This histologic and transcriptomic study of human and primate adrenal tissue samples provides a molecular framework to understand the fetal development of the adrenal gland.The adrenal cortex is the major source of steroid hormones that drive a plethora of critical ph...